(R)-Propranolol hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸右丙洛尔是抗肾上腺素受体（β-肾上腺素受体）拮抗剂普萘洛尔活性较低的对映体。

Dexpropranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.(In Vivo):Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation.

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Dexpropranolol hydrochloride | (R)-(+)-Propranolol

Angiogenesis

Adrenergic Receptor

MCH1-R|hERG

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13071-11-9

295.81

C16H22ClNO2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (845.17 mM)

Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years