(R)-Propranolol hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dexpropranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol.

Dexpropranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.(In Vivo):Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation.

Dexpropranolol hydrochloride; (R)-(+)-Propranolol

Angiogenesis

Adrenergic Receptor

MCH1-R;hERG

——

——

13071-11-9

295.8

C16H22ClNO2

>98% (HPLC)

——

Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years